Peer-reviewed veterinary case report
Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.
- Journal:
- BioMed research international
- Year:
- 2015
- Authors:
- Zhang, Lan et al.
- Affiliation:
- Department of Pediatrics · China
- Species:
- rodent
Abstract
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25883968/