Peer-reviewed veterinary case report
Anti-TNF-alpha antibody helped prevent feline infectious peritonitis
By Doki, Tomoyoshi et al.·Published in Research in veterinary science·2016·School of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis.
- Species:
- cat
Plain-English summary
Three cats that were infected with the feline infectious peritonitis virus (FIPV) were treated with a special antibody designed to block a harmful protein called TNF-alpha. This treatment helped prevent the progression of FIP in two of the three cats, while all cats in the untreated group developed the disease. The treated cats showed improvements in certain blood markers and their immune cell counts returned to normal. This suggests that the anti-TNF-alpha antibody could be an effective treatment for FIP in cats.
People also search for: cat FIP treatment · feline infectious peritonitis symptoms · TNF-alpha antibody for cats
Abstract
Feline infectious peritonitis virus (FIPV) replication in macrophages/monocytes induced tumor necrosis factor (TNF)-alpha production, and that the TNF-alpha produced was involved in aggravating the pathology of FIP. We previously reported the preparation of a feline TNF-alpha (fTNF-alpha)-neutralizing mouse monoclonal antibody (anti-fTNF-alpha mAb). This anti-fTNF-alpha mAb 2-4 was confirmed to inhibit the following fTNF-alpha-induced conditions in vitro. In the present study, we investigated whether mAb 2-4 improved the FIP symptoms and survival rate of experimentally FIPV-inoculated SPF cats. Progression to FIP was prevented in 2 out of 3 cats treated with mAb 2-4, whereas all 3 cats developed FIP in the placebo control group. Plasma alpha1-glycoprotein and vascular endothelial growth factor levels were improved by the administration of mAb 2-4, and the peripheral lymphocyte count also recovered. These results strongly suggested that the anti-fTNF-alpha antibody is effective for the treatment of FIP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26850532/