Peer-reviewed veterinary case report
Aromatase inhibitor helped infertile dogs with high estrogen levels
By Kawakami, Eiichi et al.Ā·Published in The Journal of veterinary medical scienceĀ·2003Ā·Department of Reproduction, JapanĀ·View original on PubMed ā
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Original publication title: Therapeutic effect of aromatase inhibitor in two azoospermic dogs with high plasma estradiol-17beta levels.
- Species:
- dog
Plain-English summary
Two male dogs that were unable to father puppies due to high levels of a hormone called estradiol were treated with a medication known as an aromatase inhibitor. After receiving this treatment for four weeks, their hormone levels dropped, and they began to produce some sperm. This suggests that the treatment helped improve their fertility temporarily. If your dog is having trouble breeding, discussing hormone treatments with your vet might be a good option.
People also search for: dog infertility treatment Ā· azoospermia in dogs Ā· aromatase inhibitor for dogs
Abstract
Two azoospermic dogs with high plasma estradiol-17 beta (E(2)) levels were subcutaneously injected with an aromatase inhibitor (AI), 4-androstene-4-ol-3,17-dione, 2 mg every other day for 4 weeks. Before the AI treatment the plasma E(2) levels of the two dogs (21 and 22 pg/ml, respectively) were higher than those of 2 normal dogs (8.1 and 12.3 pg/ml), and they fell to 11-17 pg/ml between 1 and 4 weeks after the start of AI treatment. The plasma testosterone levels after the start of AI treatment had increased to 2.1-3.1 ng/ml. A small number of sperm were detected in the semen of the two dogs between 3 and 6 weeks after the start of AI treatment. These results indicate that the testicular function of infertile dogs with high plasma E(2) levels can be temporarily improved by AI therapy.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/14709824/