Peer-reviewed veterinary case report
Pain relief from dexmedetomidine in cats by muscle or mouth dose
By Slingsby, Louisa S et al.·Published in Journal of feline medicine and surgery·2009·School of Clinical Veterinary Science, United Kingdom·View original on PubMed →
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Original publication title: Thermal antinociception after dexmedetomidine administration in cats: a comparison between intramuscular and oral transmucosal administration.
- Species:
- cat
Plain-English summary
A group of 12 cats received a medication called dexmedetomidine either through an injection or by placing it in their mouths to see how well it worked for pain relief and sedation. Both methods were effective, showing similar results in how much pain relief the cats felt and how sedated they became. The medication worked well for about an hour, regardless of how it was given. This means that pet owners can choose either method for their cats, as both provided effective pain management.
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Abstract
Dexmedetomidine 40microg/kg was administered either intramuscularly (IM) or oral transmucosally (OTM) to 12 cats in a randomised cross-over study. Thermal nociceptive thresholds and visual analogue scale (VAS) sedation scores were obtained before and at regular intervals up to 24h after test drug administration. The summary measures of overall mean threshold, overall mean VAS sedation plus onset, offset and duration of analgesia were investigated using a univariate general linear model. There were no significant differences between treatment groups. Data are presented as mean+/-standard deviation: delta T mean increase over time (IM 6 degrees C+/-3 degrees C, OTM 6 degrees C+/-2 degrees C); overall mean VAS (IM 43+/-9 OTM 39+/-1); onset (IM 35+/-32 and OTM 30+/-40min); offset (IM 96+/-56 and OTM 138+/-135min); duration (IM 61+/-47 OTM 99+/-124min). Dexmedetomidine is well absorbed through the oral mucosa in cats since OTM and IM administration of dexmedetomidine 40microg/kg produced similar overall sedative and antinociceptive effects.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19577498/