Peer-reviewed veterinary case report
Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats.
- Journal:
- Nanomedicine : nanotechnology, biology, and medicine
- Year:
- 2017
- Authors:
- Park, Joohyun et al.
- Affiliation:
- Department of Anatomy Yonsei University College of Medicine · South Korea
- Species:
- rodent
Abstract
Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28412143/