Peer-reviewed veterinary case report
Oxidative stress levels in dogs with hypercortisolism
By Soares, F A C et al.·Published in Domestic animal endocrinology·2021·School of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Thiobarbituric acid reactive substances in dogs with spontaneous hypercortisolism.
- Species:
- dog
Plain-English summary
A group of dogs with spontaneous hypercortisolism (a condition causing excess cortisol) had high levels of oxidative stress markers at diagnosis. After starting treatment with trilostane, their oxidative stress levels significantly decreased, indicating that the treatment helped improve their condition. By six months and one year after treatment, their oxidative stress levels were similar to those of healthy dogs. This suggests that managing hypercortisolism can reduce harmful oxidative stress in dogs.
People also search for: dog hypercortisolism treatment · trilostane for dogs · dog oxidative stress symptoms
Abstract
Thiobarbituric acid reactive substances (TBARS) are laboratory markers of oxidative stress, which can be used to evaluate the lipid peroxidation that characterizes cell membrane damage caused by excess free radicals. This prospective study aimed to assess TBARS as a parameter of lipid peroxidation in dogs with spontaneous hypercortisolism (HC) at the time of diagnosis, and after trilostane treatment. Furthermore, it aimed to investigate the correlations between TBARS levels, and laboratory and cardiovascular parameters. Sixteen dogs with HC were evaluated at 3 different time points: At diagnosis (T0), 6 mo after treatment (T1), and 12 mo after trilostane treatment (T2). A control group (n = 20) of dogs with a demographic profile similar to the HC group, but considered healthy was selected and evaluated. There was a significant difference (P < 0.001) in TBARS levels between the HC group at diagnosis (4.38 ± 1.16 nmoles MDA/mg protein) and the control group (2.15 ± 0.45 nmoles MDA/mg protein). Dogs in the HC group exhibited a significant reduction (P < 0.001) in TBARS levels after treatment. There was no significant difference in TBARS levels between the control group and the HC group at T1 and T2 evaluation. TBARS positively correlated with left atrial dimensions and hematocrit. The study demonstrates that lipid peroxidation is increased in canine HC and suggests that control of the disease is beneficial to normalize the state of oxidative stress.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34126587/