Peer-reviewed veterinary case report
Radiation therapy for large liver cancer in six dogs
By Mori, T et al.·Published in The Journal of small animal practice·2015·Department of Veterinary Clinical Oncology, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Three-dimensional conformal radiation therapy for inoperable massive hepatocellular carcinoma in six dogs.
- Species:
- dog
Plain-English summary
A group of six dogs with large liver tumors (hepatocellular carcinoma) that couldn't be surgically removed received a specialized radiation therapy called three-dimensional conformal radiation therapy (3D-CRT). The treatment involved multiple sessions of radiation, and most of the dogs showed positive responses to the therapy. One dog experienced a mild, reversible side effect related to the liver, but the others tolerated the treatment well. Overall, 3D-CRT seems to be a promising option for dogs facing this serious condition.
People also search for: dog liver cancer treatment · 3D radiation therapy for dogs · hepatocellular carcinoma in dogs · side effects of radiation therapy in dogs
Abstract
OBJECTIVES: To evaluate the activity and tolerability of three-dimensional conformal radiation therapy (3D-CRT) in dogs with massive hepatocellular carcinoma. MATERIALS AND METHODS: Six dogs with massive hepatocellular carcinoma that were ineligible for surgical resection or with owners who declined surgical resection, and underwent 3D-CRT were retrospectively reviewed. 6 to 10 Gy per fraction was prescribed at isocentre of planning target volume to a total dose of 18 to 42 Gy with 1 to 2 fractions per week for a total of 3 to 7 fractions. Follow-up examinations included physical examination, contrast-enhanced CT scan and blood analysis (complete blood count, electrolytes and serum biochemical panel). RESULTS: The median follow-up time after 3D-CRT was 534 (range, 281 to 1057) days. An objective response was observed in five of six cases. Radiation-induced liver disease developed in one dog but was asymptomatic and reversible. Toxicity was not noted in any other dog. CLINICAL SIGNIFICANCE: 3D-CRT appears to be a viable treatment option for dogs with inoperable massive hepatocellular carcinoma.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25816781/