Peer-reviewed veterinary case report
Rabies vaccine protects most dogs for three years after vaccination
By Lakshmanan, Nallakannu et al.·Published in Veterinary therapeutics : research in applied veterinary medicine·2006·Intervet Inc., United States·View original on PubMed →
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Original publication title: Three-year rabies duration of immunity in dogs following vaccination with a core combination vaccine against canine distemper virus, canine adenovirus type-1, canine parvovirus, and rabies virus.
- Species:
- dog
Plain-English summary
A group of 32 puppies received a rabies vaccine along with other core vaccines at 12 weeks of age, while 31 puppies did not get vaccinated. After three years of isolation, the vaccinated puppies were exposed to the rabies virus, and 88% of them showed no signs of rabies. In contrast, nearly all of the unvaccinated puppies died from the infection. This study shows that the rabies vaccine provides strong protection for at least three years after vaccination, without any issues from the other vaccines given at the same time.
People also search for: puppy rabies vaccine duration · rabies vaccine effectiveness in dogs · core vaccines for puppies
Abstract
Thirty-two seronegative pups were vaccinated at 8 weeks of age with modified-live canine distemper virus (CDV), canine adenovirus type-2 (CAV-2), and canine parvovirus (CPV) vaccine and at 12 weeks with a modified-live CDV, CAV-2, CPV, and killed rabies virus vaccine. An additional 31 seronegative pups served as age-matched, nonvaccinated controls. All test dogs were strictly isolated for 3 years after receiving the second vaccination and then were challenged with virulent rabies virus. Clinical signs of rabies were prevented in 28 (88%) of the 32 vaccinated dogs. In contrast, 97% (30 of 31) of the control dogs died of rabies infection. These study results indicated that no immunogenic interference occurred between the modified-live vaccine components and the killed rabies virus component. Furthermore, these results indicated that the rabies component in the test vaccine provided protection against virulent rabies challenge in dogs 12 weeks of age or older for a minimum of 3 years following vaccination.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17039445/