Peer-reviewed veterinary case report
Measuring thrombin-antithrombin complex to diagnose clotting disorder
By Rimpo, Kenji et al.·Published in PloS one·2018·Saitama Animal Medical Center, Japan·View original on PubMed →
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Original publication title: Thrombin-antithrombin complex measurement using a point-of-care testing device for diagnosis of disseminated intravascular coagulation in dogs.
- Species:
- dog
Plain-English summary
A study looked at how measuring a specific blood protein called thrombin-antithrombin complex (TAT) can help diagnose a serious condition in dogs called disseminated intravascular coagulation (DIC). Researchers found that dogs with DIC had higher TAT levels, especially if they showed multiple abnormal test results. Healthy dogs had much lower TAT levels, which helps set a reference for what’s normal. The findings suggest that using an in-house TAT test could be a helpful tool for veterinarians to detect DIC early in dogs, potentially leading to quicker treatment.
People also search for: dog bleeding problems · DIC in dogs symptoms · thrombin-antithrombin complex test for dogs
Abstract
Reference interval for thrombin-antithrombin complex (TAT) level was determined using an in-house TAT measurement device, and its validity for diagnosis of disseminated intravascular coagulation (DIC) was evaluated in dogs. One hundred and two clinically healthy dogs and 247 diseased dogs with conditions that potentially caused DIC were recruited in the study. Six diagnostic testing for DIC were evaluated in diseased dogs and the diseased dogs were categorized into five groups depending on abnormal findings. TAT was measured in all study animals and between-group differences were evaluated. TAT level was positively associated with severity of DIC. There were no significant differences in TAT levels among clinically healthy dogs, diseased dogs without any abnormal finding and diseased dogs with one abnormal finding in the DIC diagnostic testing. TAT levels in groups with two or more abnormal findings were significantly higher than clinically healthy dogs. Reference interval of TAT level for clinically healthy dogs was ≤ 0.25 ng/ml. Validity of using TAT for early detection of DIC was evaluated. In-house TAT measurement was suggested to be a clinically relevant and useful tool for early detection of canine DIC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30304025/