Peer-reviewed veterinary case report
Causes and conditions linked to high platelet counts in dogs
By Neel, Jennifer A et al.·Published in Veterinary clinical pathology·2012·Department of Population Health and Pathobiology, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Thrombocytosis: a retrospective study of 165 dogs.
- Species:
- dog
Plain-English summary
A group of 165 dogs was found to have high platelet counts, a condition known as thrombocytosis, which can be linked to various health issues. Most of these dogs had underlying problems like cancer or inflammation, with common cancers being lymphomas and mast cell tumors. Some dogs had received treatments like glucocorticoids or vincristine, which can also cause high platelet levels. While thrombocytosis can lead to complications like blood clots, it was primarily a sign of other serious conditions in these dogs. Treatment focused on addressing the underlying diseases, which helped manage their health.
People also search for: dog high platelet count causes · dog cancer symptoms · treatment for dog inflammation · dog blood clot treatment · glucocorticoids side effects in dogs
Abstract
BACKGROUND: Thrombocytosis has been associated with various conditions, including inflammation, neoplasia, iron deficiency, splenectomy, and drug administration. OBJECTIVE: The aim of this study was to characterize diseases and conditions associated with thrombocytosis in dogs. METHODS: In this retrospective study, dogs with thrombocytosis (platelet count > 600 × 10(3) /μL) and complete medical records during a 1-year period were included, and breed, sex, age, CBC results, alkaline phosphatase and gamma-glutamyltransferase activities in some dogs, administration of glucocorticoids or vincristine, and primary diagnosis were evaluated. RESULTS: Thrombocytosis was found in 240 of 5342 dogs (4.6%), and 165 (3.1%) met inclusion criteria. Thrombocytosis was secondary in all dogs, and underlying diseases and conditions (n,%) were neoplasia (56, 33.9%), inflammation (55, 33.3%), miscellaneous disorders (26, 15.8%), neoplasia plus a second disease (13, 7.9%), endocrine diseases (8, 4.8%), and multiple diseases (7, 4.2%). In dogs with neoplasia, carcinomas (24) and round cell neoplasms (20), especially lymphoma and mast cell tumor, were the most frequent tumors. Inflammatory disorders consisted of immune-mediated disorders (11), neurologic diseases (8), infectious diseases (6), allergic disease (5), orthopedic diseases (4), gastrointestinal diseases (4), and miscellaneous conditions (17). Of the 165 dogs, 73 (44.2%) had received glucocorticoids (55) or vincristine (18) Marked (850-969 × 10(3) platelets/μL) or extreme ( ≥ 970 × 10(3) platelets/μL) thrombocytosis occurred in 24 (14.5%) dogs; 12 (50.0%) had neoplasia. Thromboembolism occurred in 13 (7.9%) dogs. CONCLUSIONS: Thrombocytosis in dogs occurred most frequently secondary to neoplastic and inflammatory diseases and was commonly associated with glucocorticoid and vincristine administration. Thromboembolic complications occurred in a small number of patients. Marked or extreme thrombocytosis was more likely to occur with neoplasia than with other conditions.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22390566/