Peer-reviewed veterinary case report
Dog with acute megakaryoblastic leukemia and brain involvement
By Rochel, Daphné et al.·Published in Veterinary Clinical Pathology·2018·Oniris Department of Biology, Pathology and Food Sciences Nantes Atlantic College of Veterinary Medicine, Food Science and Engineering Nantes France, France·View original on Crossref →
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Original publication title: Thrombocytosis and central nervous system involvement in a case of canine acute megakaryoblastic leukemia
- Species:
- dog
Plain-English summary
A 14-month-old female Poodle mix was brought to the vet with signs of illness, and tests revealed she had acute megakaryoblastic leukemia, a type of blood cancer. The vet found a very high number of abnormal platelets and blast cells in her blood, along with serious involvement of her liver, spleen, lymph nodes, lungs, kidneys, and brain. Unfortunately, despite ongoing monitoring and treatment, her condition continued to worsen due to the aggressive nature of the leukemia. This case highlights the importance of recognizing blood abnormalities in young dogs, as they can indicate serious health issues.
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Abstract
AbstractThis case report presents a 14‐month‐old female Poodle mix with acute megakaryoblastic leukemia based on a marked thrombocytosis, abnormal platelet morphology, circulating dwarf megakaryocytes, and blast cells in the blood. Bone marrow abnormalities included dysmegakaryopoiesis dygranulopoiesis, and an increased number of blast cells was observed in the blood. Extensive leukemic involvement was also found in the liver, spleen, lymph nodes, lungs, kidneys, and brain. The cytopathologic features of the abnormal circulating cells were highly suggestive of being megakaryocytic in origin, which was supported by negative myeloperoxidase staining and positive von Willebrand factor staining on immunocytochemistry (ICC). The neoplastic cells were also CD61 positive and had variable von Willebrand factor expression on ICC. Although there were only 25% blast cells in the bone marrow, which theoretically supported myelodysplastic syndrome, the hypothesis that this case represented acute myeloid leukemia of megakaryoblastic origin was confirmed by the continuous increase in circulating blast cell numbers during follow‐up visits and the extensive leukemic involvement of parenchymal organs.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vcp.12642