Peer-reviewed veterinary case report
Thrombocytosis in 715 dogs linked to cancer and inflammation
By Woolcock, A D et al.·Published in Journal of veterinary internal medicine·2017·Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Thrombocytosis in 715 Dogs (2011-2015).
- Species:
- dog
Plain-English summary
A group of 715 dogs with high platelet counts (thrombocytosis) was studied to understand the causes and severity of this condition. Many of these dogs had underlying issues such as cancer, endocrine disorders, or inflammatory diseases, with cancer being the most common cause. Interestingly, dogs with immune-mediated diseases often had higher platelet counts, especially if they were receiving glucocorticoid medications. The findings suggest that if your dog has thrombocytosis, it could be linked to serious health issues, and further evaluation by a veterinarian is important for proper diagnosis and treatment.
People also search for: dog high platelet count causes · thrombocytosis in dogs treatment · dog cancer symptoms · immune-mediated disease in dogs
Abstract
BACKGROUND: Thrombocytosis is a hematologic abnormality in dogs that has been associated with various neoplastic, metabolic, and inflammatory conditions. OBJECTIVE: To classify thrombocytosis in dogs based on severity and evaluate whether there are associations between severity and underlying disease processes. ANIMALS: Seven hundred and fifteen dogs with thrombocytosis and 1,430 dogs with normal numbers of platelets. METHODS: Retrospective study. Medical records of dogs with increased (>500 × 10/μL; thrombocytosis group) and normal (300-500 × 10/μL; control group) platelet counts between 2011 and 2015 were reviewed. Dogs were characterized by severity of platelet increase and diagnosis. Diagnostic categories included neoplasia, endocrine disease, inflammatory disease, or miscellaneous. RESULTS: A total of 1,254 complete blood counts with thrombocytosis from 715 dogs were included in the study. Median platelet count in this population was 582 × 10/μL (500-1,810 × 10/μL). No correlation between severity of thrombocytosis and diagnosis was identified. Causes of secondary thrombocytosis included neoplasia (55.7%), endocrine disease (12.0%), and inflammatory disease (46.6%). Immune-mediated disease was common (22.2%), associated with frequent glucocorticoid administration, and had a significantly higher median platelet count (636 × 10/μL [500-1,262 × 10/μL] versus 565 × 10/μL [500-1,810 × 10/μL]) when compared to the other inflammatory processes (P < 0.001). The diagnoses in the thrombocytosis dogs differed significantly from the control population (P < 0.001). CONCLUSIONS AND CLINICAL IMPORTANCE: Thrombocytosis is commonly associated with carcinoma and immune-mediated disease in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28895208/