Peer-reviewed veterinary case report
Blood clotting changes in dogs after liver tumor surgery
By Fontes, Gabrielle S. et al.·Published in Veterinary and Comparative Oncology·2023·Department of Veterinary Clinical Sciences The Ohio State University College of Veterinary Medicine Columbus Ohio USA, United States·View original on Crossref →
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Original publication title: Thromboelastographic results and hypercoagulability in dogs with surgically treated hepatocellular adenoma and carcinoma: A Veterinary Society of Surgical Oncology prospective study
- Species:
- dog
Plain-English summary
A group of dogs with liver tumors, including adenomas and carcinomas, were studied to see how their blood clotting ability changed before and after surgery. The dogs showed higher platelet counts and increased hypercoagulability (a tendency for blood to clot more easily) compared to healthy dogs at all measured times. This hypercoagulability was linked directly to the liver tumors, not the surgery itself. The findings suggest that dogs with liver tumors may need careful monitoring for blood clotting issues even after surgery.
People also search for: dog liver tumor symptoms · dog surgery recovery bleeding · hypercoagulability in dogs
Abstract
AbstractBackgroundThe most common haemostatic abnormality in dogs with cancer is hypercoagulability. A transient hypercoagulability has been documented in people with hepatocellular carcinoma (HCC) that resolves within weeks following hepatic tumour resection.ObjectiveThe objective was to compare the haemostatic status of dogs with liver tumours and healthy control dogs, by comparing coagulation and thromboelastography (TEG) measurements at three time points.MethodsLiver tumour and healthy control dogs receiving surgery for liver lobectomy and ovariohysterectomy, respectively, were prospectively enrolled. All dogs had blood collected at three time points: pre‐operative, 24 h post‐operative and ~2 weeks post‐operative. Haematological and haemostatic values were compared across time points in each group using repeated measures ANOVA tests.ResultsTen and eight dogs were enrolled for the liver and control groups, respectively. Platelet count was significantly higher in the liver group than the control group at all time points, but within the normal range (pre‐operative: 438.7 vs. 300.9 × 109/L, p = .0078; 24 h post‐operative: 416.2 vs. 283.9 × 109/L, p = .0123; 10–14 days post‐operative: 524.6 vs. 317.3 × 109/L, p = .0072). The measure of the overall coagulant state (G‐value) was significantly increased for the liver group compared to the control group at all time points (pre‐operative: 15.6 vs. 8.6 d/sc, p = .0003; 24 h post‐operative: 18.3 vs. 11.2 d/sc, p = .039; 10–14 days post‐operative: 15.1 vs. 9.6 d/sc, p = .015).ConclusionThe liver group was hypercoagulable based on elevated G‐values at all time points compared to the control group. This hypercoagulability was attributed to the effect of hepatic tumours alone, and not secondary to surgery and anaesthesia.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.12924