Peer-reviewed veterinary case report
Blood clots in dogs with protein-losing intestinal disease
By Jacinto, Ana M L et al.·Published in Journal of the American Animal Hospital Association·2017·View original on PubMed →
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Original publication title: Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease.
- Species:
- dog
Plain-English summary
A group of dogs with protein-losing enteropathy (PLE), a condition that causes severe protein loss through the intestines, were found to be at risk for serious blood clots. In this case series, six out of eight dogs experienced pulmonary thromboembolism (blood clots in the lungs), which can be life-threatening. Unfortunately, six of these dogs did not survive. The study highlighted that dogs with poorly controlled PLE are particularly vulnerable to these dangerous complications. If your dog has PLE, it's important to monitor their condition closely and discuss any concerns with your veterinarian.
People also search for: dog protein-losing enteropathy symptoms · dog blood clots treatment · why is my dog losing weight and protein
Abstract
Dogs with protein-losing enteropathy (PLE) are suggested to be at increased risk of developing thromboembolic events. However, with some exceptions, there are very few reports of thromboembolism in such dogs. This multicentre retrospective observational study describes a case series of thromboembolism (TE) in eight dogs with PLE secondary to non-neoplastic, chronic small intestinal disease. Seven dogs had poorly controlled PLE when the thromboembolic event occurred. Pulmonary thromboembolism (PTE) occurred in six dogs, while one dog developed splenic vein thrombosis and another had concurrent splenic vein and aortic TE. Six dogs died, all with PTE. Antithrombin activity was decreased in one of two dogs in which it was measured. Serum cobalamin and folate concentrations were measured in three dogs and cobalamin was subnormal in all three. Serum magnesium, measured in two dogs, was low in both. Dogs with uncontrolled chronic small intestinal disease and PLE are at risk for developing serious life-threatening TE, mostly PTE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27841681/