Peer-reviewed veterinary case report
Bleeding problems from platelet disorders in two young dogs
By Callan, M B et al.·Published in Journal of the American Animal Hospital Association·2001·Department of Clinical Studies, United States·View original on PubMed →
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Original publication title: Thrombopathies causing bleeding in a boxer and mixed-breed dog.
- Species:
- dog
Plain-English summary
A 2-year-old Boxer and a 3-year-old mixed-breed dog were brought in for bleeding problems, showing signs of excessive bleeding despite having normal blood tests. Both dogs had prolonged bleeding times when their gums were tested, indicating issues with how their platelets functioned. Further tests revealed that their platelets did not respond properly to certain stimuli, suggesting a problem with how the platelets communicate and work together. While the exact cause of their bleeding issues was not fully determined, the dogs may have inherited conditions affecting their platelet function. Treatment options would depend on the specific diagnosis and could include managing bleeding episodes as they arise.
People also search for: dog bleeding problems · Boxer bleeding disorder · mixed-breed dog platelet issues · dog platelet function disorder treatment
Abstract
Hereditary platelet function disorders are clinically characterized by recurrent surface bleeding and prolonged bleeding time, despite normal platelet count and coagulation tests. The authors describe persistent thrombopathies in two young dogs with increased bleeding tendencies but with normal plasma coagulation times and von Willebrand factor (vWf) concentrations. Buccal mucosal bleeding times were prolonged in both dogs. In aggregation studies, platelets underwent only a shape change or minimal aggregation in response to adenosine diphosphate and collagen. Whole-platelet adenine nucleotide concentrations were normal. Electron microscopic evaluation of fibrinogen and vWf binding to the platelets of case no. 1 demonstrated the presence of glycoprotein IIb/IIIa and Ib receptors. Thus, the intrinsic platelet function defects may be different in these two dogs and may likely represent secretion/signal transduction disorders.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11361116/