Peer-reviewed veterinary case report
Thrombopoietin is ineffective in a mouse model of motor neuron disease.
- Journal:
- Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
- Year:
- 2008
- Authors:
- Caraganis, Andrew et al.
- Affiliation:
- Department of Neurology · United States
- Species:
- rodent
Abstract
This study assessed the therapeutic efficacy of thrombopoietin (TPO) in the mouse model of ALS using two treatment paradigms. TPO was administered either daily or in 13-day treatment cycles to SOD1-G93A mice. Quantitative analysis of platelet levels, VEGF and TGF-beta1 trophic factors were assessed. The effect of TPO on disease progression was analyzed by behavioral analysis and clinical examination. TPO treatment increased levels of platelets and TGF-beta1 but not VEGF. This treatment did not affect onset or survival in these mice. Although biologically active, demonstrated by increased platelet and TGF-beta1 levels, rmTPO did not attenuate disease progression in ALS mice.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18608089/