Peer-reviewed veterinary case report
Dog with thymus cysts and bleeding from brodifacoum poisoning
By Rickman, B H & Gurfield, N·Published in Veterinary pathology·2009·Department of Agriculture, United States·View original on PubMed →
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Original publication title: Thymic cystic degeneration, pseudoepitheliomatous hyperplasia, and hemorrhage in a dog with brodifacoum toxicosis.
- Species:
- dog
Plain-English summary
A 7-month-old female American Eskimo Dog sadly died after suffering from brodifacoum poisoning, which is a type of rat poison. The dog showed severe internal bleeding in the chest and had abnormal growths in the thymus gland, which is important for the immune system. Unfortunately, the damage was extensive, and the thymus was not functioning properly. This case highlights the serious effects of rat poison on dogs, leading to life-threatening complications.
People also search for: dog rat poison symptoms · American Eskimo Dog poisoning treatment · thymus problems in dogs
Abstract
Thymic cysts with pseudoepitheliomatous hyperplasia are described in a 7-month-old female American Eskimo Dog that died of complications from brodifacoum poisoning. Grossly, there was hemothorax with marked cranial mediastinal hemorrhage. Histologically, thymic lobules were expanded and distorted by irregular cysts, lined by single to multiple layers of plump to slightly attenuated polygonal squamous epithelial cells supported by a basement membrane (pseudoepitheliomatous hyperplasia). The thymus had a paucity of lymphocytes and lacked corticomedullary differentiation. Extensive hemorrhage within the cysts and thymic parenchyma extended into the adjacent adipose tissue. To the authors' knowledge, this is the first report of cystic thymic degeneration with pseudoepitheliomatous hyperplasia in a nonhuman species.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19176509/