Peer-reviewed veterinary case report
Dog with thymoma tumor and high T-cell lymphocytes in blood
By Burton, Andrew G. et al.·Published in Veterinary Clinical Pathology·2014·Veterinary Medical Teaching Hospital University of California‐Davis Davis CA USA, United States·View original on Crossref →
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Original publication title: Thymoma‐associated lymphocytosis in a dog
- Species:
- dog
Plain-English summary
A 9-year-old female spayed English Springer Spaniel was brought to the vet for a mass in her chest and high levels of certain white blood cells (lymphocytosis). Tests showed that the mass was a thymoma, which is a type of tumor in the thymus gland. After the tumor was surgically removed, the dog's lymphocyte levels returned to normal, confirming that the thymoma was causing the issue. This case is significant as it highlights a rare condition in dogs related to thymoma and its effects on blood cell levels.
People also search for: dog thymoma symptoms · English Springer Spaniel lymphocytosis treatment · dog chest mass removal recovery
Abstract
AbstractA 9‐year‐old female spayed English Springer Spaniel was evaluated for a cranial mediastinal mass and lymphocytosis. Flow cytometric immunophenotyping of peripheral blood lymphocytes revealed 97% asCD3 positive, confirming a T‐cell lineage. Additionally, T‐cell subset assessment showed 53.2% to be double‐negative T‐lymphocytes, expressing neitherCD4 norCD8 surface markers. The number of double‐negative lymphocytes in circulation coincided with the number of T‐cell receptor (TCR) γδ‐expressing T‐cells in circulation. Molecular T‐cell clonality analysis of TCR Gamma (TCRG) gene rearrangement showed a polyclonal expansion of T‐lymphocytes. Histopathology confirmed the mass to be a thymoma, supporting the diagnosis of thymoma‐associated T‐cell lymphocytosis. Resolution of the lymphocytosis after removal of the thymoma provided further evidence for this diagnosis. To the authors' knowledge, this case is only the second report of thymoma‐associated peripheral lymphocytosis in the veterinary literature, and is the first to report a confirmed thymoma‐associated peripheral γδ T‐cell lymphocytosis in a dog.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vcp.12196