Peer-reviewed veterinary case report
Dog with thymoma tumor and high T-cell lymphocytes in blood
By Burton, Andrew G et al.·Published in Veterinary clinical pathology·2014·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Thymoma-associated lymphocytosis in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old female spayed English Springer Spaniel was brought in for evaluation of a mass in her chest and an unusually high number of lymphocytes (a type of white blood cell) in her blood. Tests confirmed that the mass was a thymoma, which is a tumor of the thymus gland. After the thymoma was surgically removed, the dog's lymphocyte levels returned to normal, indicating that the high lymphocyte count was related to the tumor. This case highlights a rare condition where a thymoma can cause changes in blood cell counts in dogs.
People also search for: dog thymoma symptoms · English Springer Spaniel lymphocytosis · dog thymoma treatment
Abstract
A 9-year-old female spayed English Springer Spaniel was evaluated for a cranial mediastinal mass and lymphocytosis. Flow cytometric immunophenotyping of peripheral blood lymphocytes revealed 97% as CD3 positive, confirming a T-cell lineage. Additionally, T-cell subset assessment showed 53.2% to be double-negative T-lymphocytes, expressing neither CD4 nor CD8 surface markers. The number of double-negative lymphocytes in circulation coincided with the number of T-cell receptor (TCR) γδ-expressing T-cells in circulation. Molecular T-cell clonality analysis of TCR Gamma (TCRG) gene rearrangement showed a polyclonal expansion of T-lymphocytes. Histopathology confirmed the mass to be a thymoma, supporting the diagnosis of thymoma-associated T-cell lymphocytosis. Resolution of the lymphocytosis after removal of the thymoma provided further evidence for this diagnosis. To the authors' knowledge, this case is only the second report of thymoma-associated peripheral lymphocytosis in the veterinary literature, and is the first to report a confirmed thymoma-associated peripheral γδ T-cell lymphocytosis in a dog.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25295998/