Peer-reviewed veterinary case report
Thyroxine replacement in an animal model of congenital hypothyroidism.
- Journal:
- Physiology & behavior
- Year:
- 2007
- Authors:
- Reid, Rosemary E et al.
- Affiliation:
- School of Psychology
- Species:
- rodent
Abstract
This study examined the effects of thyroxine (T(4)) treatment on spatial learning and memory in congenitally hypothyroid (CH) rats. Forty CH male offspring of methimazole-treated dams were randomly divided into three groups: no T(4) (vehicle) treatment (n=12), T(4) treatment commencing on postnatal day (P-) 7 (n=14), and T(4) treatment commencing on P-21 (n=14). Normal male rats were used as a control group (n=14). T(4) was administered daily (sc, 0.02 microg/g) to the treatment groups for 30 days. A water-maze was used to assess behaviour at 42, 70 and 98 days of age. T(4) treatment beginning at P-7 improved learning and memory associated with CH at 70 and 98 days of age but T(4) treatment beginning at P-21 did not improve CH-impaired learning and memory.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17445845/