Peer-reviewed veterinary case report
Immune response to canine distemper vaccine in tigers and cats
By McEntire, Michael et al.·Published in Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2020·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: TIGER () AND DOMESTIC CAT () IMMUNE RESPONSES TO CANARYPOX-VECTORED CANINE DISTEMPER VACCINATION.
- Species:
- cat
Plain-English summary
A group of domestic cats was tested to see how well they responded to a new canine distemper vaccine delivered through different methods. The cats that received the vaccine through a subcutaneous injection showed a strong immune response, with antibody levels rising significantly after vaccination. In contrast, cats that received saline injections or oral doses did not develop any immunity. The study found that the subcutaneous vaccination was safe and effective for domestic cats, providing lasting protection against canine distemper.
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Abstract
Two methods for delivering a canarypox-vectored canine distemper vaccine to tigers () and domestic cats () were investigated. Eight tigers were divided randomly into two vaccination groups: subcutaneous injection or topical tonsillar application. Each tiger received 2 ml of canine distemper virus (CDV) vaccine (Merial Ferret Distemper Vaccine). Blood was collected from tigers on days 0, 21, 35 or 37, and 112 post-initial vaccination (PIV). Domestic cats were divided randomly into four treatment groups: saline injection (negative controls), low- and high-dose oral, and subcutaneous vaccinates. Blood was collected from domestic cats on days 0, 7, 21, and 28 and 165 or 208 PIV. Sera were tested for CDV antibodies by virus neutralization. All individuals were seronegative at the beginning of the study. One tiger vaccinated subcutaneously developed a titer of 32 by day 35, which reduced to 16 by day 112. Another tiger vaccinated by tonsillar application developed a titer of 8 on day 112. All other tigers remained seronegative. Cats that received saline injection or oral vaccination remained seronegative at each sampling time. Domestic cats vaccinated subcutaneously developed titers ranging from 4 to >128 by day 28, and those re-bled at day 166 had titers of 16 or 64. The disparity in response between domestic cats and tigers may be due to species differences or it may represent a dose-dependent effect. Subcutaneous vaccination with canarypox-vectored Purevax Ferret Distemperis safe and elicits persistent antibody titers in domestic cats vaccinated parenterally.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31926509/