Peer-reviewed veterinary case report
Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations.
- Journal:
- Journal of clinical microbiology
- Year:
- 2012
- Authors:
- Orrù, Christina D et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases · United States
- Species:
- rodent
Abstract
To assess prospects for early diagnosis of prion disease based on prion seeding activity in cerebrospinal fluid (CSF), we measured the activity over time in scrapie-infected hamsters by real-time quaking-induced conversion (RT-QuIC). After intracerebral inoculation, activity appeared in CSF within 1 day and plateaued weeks before the onset of clinical signs. However, after intratongue inoculation, activity first appeared in CSF with the onset of clinical signs, well after higher-level accumulation of seeding activity in brain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22238438/