Peer-reviewed veterinary case report
Mesh and stem cell secretions improve tissue healing in low-estrogen
By Dewi TIT et al.·2025·School of Veterinary Medicine and Biomedical Sciences·View original on Europe PMC →
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Original publication title: Tissue integrity and healing response in hypoestrogenic animal model treated by mesh implantation with addition of mesenchymal stem cell secretome.
- Species:
- rabbit
Plain-English summary
This study looked at how adding a special substance from umbilical cord stem cells could help improve healing and reduce tissue damage in rabbits that had surgery for pelvic organ prolapse, a condition that can happen when the pelvic organs drop due to weakened tissues. The researchers used 32 female rabbits that had their ovaries removed to create a condition similar to low estrogen levels, which can affect healing. They divided the rabbits into two groups: one received standard mesh for support, while the other received mesh along with the stem cell substance. Over 90 days, the rabbits that received the stem cell substance showed significantly better healing, with more new blood vessels, more healing cells, and better collagen formation compared to those that only had the standard mesh. Overall, the addition of the stem cell substance improved tissue integrity and helped the healing process.
Abstract
<h4>Background</h4>Pelvic organ prolapse increases in prevalence and incidence in older women and hypoestrogenic conditions. Treatment with native tissue surgery has a fairly high recurrence rate. Mesh-augmented surgery is one of the most promising treatments for pelvic organ prolapse, with high effectiveness and low recurrence. Mesh-augmented surgery has a side effect of tissue erosion. The addition of secretome is expected to improve tissue integrity and reduce tissue erosion.<h4>Aim</h4>This study aimed to investigate the effect of adding the umbilical cord mesenchymal stem cell (UC-MSC) secretome on preventing tissue inflammatory responses, improving tissue integrity, and accelerating wound healing.<h4>Methods</h4>A total of 32 female New Zealand white rabbit hypoestrogenic models were divided into two groups: the control group with normal mesh and the secretome group with artificial mesh. Hypoestrogenic models were created using the bilateral ovariectomy method. Mesh implantation was performed using a surgical method on hypoestrogenic rabbits. The animals were euthanized on days 7, 14, 28, and 90 after mesh implantation. Histopathology parameters included angiogenesis formation, fibroblast number, and collagen deposition area.<h4>Result</h4>The results of this study showed that the number of angiogenesis, fibroblast, and collagen deposition data in the secretome group showed higher significantly <i>(p</i> < 0.05) than those in the control group on days 7, 14, 28, and 90 post mesh implantation. The formation of new blood vessels (angiogenesis) in the secretome group demonstrated a mean value of 9.81 ± 2.2 compared to 0.37 ± 0.03 in the control. The number of fibroblasts in the secretome group averaged 151.00 ± 8.14, in contrast to 34.00 ± 13.37 in the control group. Collagen formation in the secretome group was also higher, with a mean value of 80.02 ± 6.71 compared to 59.49 ± 4.61 in the control group over 90 days of observation.<h4>Conclusion</h4>The administration of secretomes from UC-MSC improved tissue integrity and accelerated wound healing.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/40092191