Peer-reviewed veterinary case report
Nasal tumor shrank with toceranib and firocoxib in dog
By Osada, Hironari et al.·Published in The Journal of veterinary medical science·2023·Tokyo University of Agriculture and Technology, Japan·View original on PubMed →
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Original publication title: Toceranib phosphate and firocoxib-mediated partial response in a dog with advanced intranasal sarcoma.
- Species:
- dog
Plain-English summary
A 9-year-old mixed-breed dog was brought in for sneezing and noisy breathing that had been worsening over three months. A CT scan showed a tumor in the left nasal cavity, diagnosed as intranasal sarcoma (a type of cancer). The dog was treated with a combination of toceranib phosphate and firocoxib, which helped shrink the tumor. After the initial treatment, the dog lived for another 205 days, suggesting that this combination could be a helpful option for dogs with this type of cancer.
People also search for: dog sneezing and breathing problems · intranasal sarcoma treatment for dogs · toceranib phosphate for dog cancer
Abstract
A nine-year-old, castrated male mixed-breed dog presented with a three-month history of sneezing and stertorous breathing. Computed tomography revealed a soft tissue mass in the left nasal cavity with lysis of the cribriform plate. The mass was diagnosed as intranasal sarcoma based on histopathological analysis. The tumor cells were immunohistochemically positive for KIT and platelet-derived growth factor receptor α/β and negative for vascular endothelial growth factor receptor 2 and cyclooxygenase-2. Treatment with toceranib phosphate (TOC) and firocoxib reduced the tumor size, which was defined as partial response (PR). After PR induction, TOC alone mediated survival for 205 days. This case report suggests that the combination of TOC and possibly firocoxib may be a therapeutic option for canine intranasal sarcoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37532540/