Peer-reviewed veterinary case report
Dog's heart obstruction from tumor improved with toceranib phosphate
By Gregory, J et al.·Published in Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2022·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Toceranib phosphate resolves right heart obstruction secondary to a heart base neoplasm in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old male Labrador retriever was brought in for coughing and rapid breathing that had lasted for two weeks. An ultrasound of his heart showed a large mass causing pressure on the right side of his heart, leading to heart failure and fluid buildup in his abdomen. The mass was identified as a type of cancer called neuroendocrine carcinoma. He was treated with a medication called toceranib phosphate, which significantly shrank the mass within four weeks, relieving the pressure on his heart. He was also given other medications to help manage his heart failure symptoms.
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Abstract
An eight-year-old castrated male, 45 kg labrador retriever presented for evaluation of a two-week history of cough and tachypnoea. Echocardiography revealed an approximately 10 cm heart base mass, which extended to the right atrioventricular junction, causing compression of both the right atrium and ventricle resulting in right-sided congestive heart failure (abdominal effusion). Cytology of the mass was consistent with a neuroendocrine carcinoma. Given the location and description, a chemodectoma or ectopic thyroid carcinoma was suspected. The patient was treated with toceranib phosphate and famotidine. At the follow-up appointment four weeks later, the right heart compression had resolved due to a clinically significant reduction in the size of the mass. The patient was prescribed furosemide and enalapril to treat right-sided congestive heart failure. When considering treatment options for haemodynamically significant heart base masses, treatment with toceranib phosphate may result in rapid clinical benefit.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36356366/