Peer-reviewed veterinary case report
Safety and effects of 2-Aminoethyl Dihydrogen Phosphate in dogs
By Januário, Eric Vieira et al.·Published in Frontiers in veterinary science·2022·Department of Surgery, Brazil·View original on PubMed →
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Original publication title: Tolerability and Effects of 2-Aminoethyl Dihydrogen Phosphate in Dogs With Mast Cell Tumors.
- Species:
- dog
Plain-English summary
Ten dogs with mast cell tumors, a type of skin cancer, were treated with a new drug called 2-Aminoethyl Dihydrogen Phosphate after their tumors were surgically removed. The treatment involved giving the dogs this medication through an IV for four weeks. Fortunately, no serious side effects were observed, and the dogs' blood counts remained stable. On average, the dogs lived tumor-free for about 600 days and had an overall survival time of around 755 days. However, the treatment did not effectively prevent the return of the tumors or the development of new ones.
People also search for: dog mast cell tumor treatment · mast cell tumor survival rate · 2-Aminoethyl Dihydrogen Phosphate for dogs
Abstract
Canine mast cell tumor is a malignant neoplasm, and a gold standard treatment remains to be determined despite the proposed chemotherapies or other therapies in dogs. This study aimed to determine therapeutic, adverse effects and toxicity, tumor-free, and overall survival times of 10 dogs with surgically excised mast cell tumors evaluated by histopathological/immunohistochemistry and treated with four weekly intravenous administrations of 2-Aminoethyl Dihydrogen Phosphate (70 mg/kg) as adjuvant therapy. No adverse events were noted. Laboratory changes were limited (< 0.05) in red blood cell, hemoglobin, and platelet counts. Mean tumor-free and overall survival were 599.1 ± 469 and 755.5 ± 423.5 days, respectively. In conclusion, 2-Aminoethyl Dihydrogen Phosphate administration was safe in dogs. However, 2-Aminoethyl Dihydrogen Phosphate was not sufficiently effective to prevent a recurrence, new tumor, or metastasis of canine mast cell tumors with poor immunohistochemical prognostic factors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35903136/