Peer-reviewed veterinary case report
Benazepril reduces protein in urine of cats with kidney disease
By King, Jonathan N et al.·Published in Journal of veterinary internal medicine·2006·Novartis Animal Health Inc·View original on PubMed →
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Original publication title: Tolerability and efficacy of benazepril in cats with chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were given a medication called benazepril to see if it could help reduce protein in their urine, a common issue with this condition. The study involved 192 cats, and those treated with benazepril showed a significant decrease in protein levels compared to those who received a placebo. While the overall survival time of the kidneys didn't differ much between the two groups, cats on benazepril had a better appetite and maintained higher protein levels in their blood. Overall, benazepril was well tolerated and helped manage one of the symptoms of CKD.
People also search for: cat chronic kidney disease treatment · benazepril for cats · cat protein in urine treatment
Abstract
The objective of the study was to test the effect of the angiotensin-converting enzyme inhibitor (ACEI) benazepril in cats with chronic kidney disease (CKD). A total of 192 cats with CKD with an initial plasma creatinine concentration > or = 2 mg/dL (> or = 177 micromol/L) and urine specific gravity < or = 1.025 were recruited into a double-blind, parallel-group, prospective, randomized clinical trial. Cats received daily (q24h) PO placebo (n = 96) or benazepril x HCl at a dosage of 0.5-1.0 mg/kg (n = 96) for up to 1,119 days. Most cats were fed exclusively a diet containing low amounts of phosphate, protein, and sodium. Benazepril produced a significant reduction in proteinuria, assessed by the urine protein-to-creatinine ratio (UPC, P = .005). This effect of benazepril was present in all subgroups tested, including cats with UPC <0.2, although the effect was largest in cats with higher UPCs. Plasma protein was maintained at higher concentrations with benazepril as compared with placebo during treatment in cats with initial UPC <1 (P = .038 versus P = .079 for all cats). There was no difference in renal survival time between the 2 groups when all 192 cats were compared. Mean +/- SD renal survival times were 637 +/- 480 days with benazepril and 520 +/- 323 days with placebo (P = .47). Mean +/- SD renal survival times in the 13 cats with initial UPC > or = 1 were 402 +/- 202 days with benazepril and 149 +/- 90 days with placebo (P = .27). Cats with initial UPC > or = 1 treated with benazepril had better appetite (P = .017) as compared with those treated with placebo. Benazepril was well tolerated. In conclusion, benazepril decreased proteinuria in cats with CKD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17063696/