Peer-reviewed veterinary case report
Are higher enrofloxacin ear drops safe for healthy dogs?
By Clegg, Jennifer et al.·Published in Journal of the American Animal Hospital Association·2023·From the Department of Veterinary Clinical Medicine, United States·View original on PubMed →
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Original publication title: Tolerability of Otic Solutions Containing Different Enrofloxacin Concentrations in Dogs with Healthy Ears.
- Species:
- dog
Plain-English summary
A group of 16 dogs with healthy ears received different concentrations of enrofloxacin, an antibiotic, to see how well they tolerated it. The dogs had no signs of ear problems before treatment, and throughout the study, their ear health remained normal with no signs of inflammation. This suggests that both concentrations of the enrofloxacin solution were safe for use in their ears. The findings indicate that these solutions could be effective options for treating dogs with bacterial ear infections in the future.
People also search for: dog ear infection treatment · enrofloxacin for dogs · safe ear drops for dogs
Abstract
Otitis externa (OE) is a common disease in dogs, and topical medications are the preferred treatment. Compounded solutions of enrofloxacin are commonly used in practice to treat bacterial OE; however, the tolerability of different concentrations of this antibiotic in the ear canals of dogs has not been evaluated. The objective of this study is to determine if a higher concentration of enrofloxacin applied to the external ear canal is clinically tolerated in dogs with healthy ears. Sixteen client-owned dogs with bilateral healthy ears and no previous history of OE were enrolled. Injectable enrofloxacin 2.27% diluted with sterile sodium chloride in 1:1 (11.35 mg/mL) and 2:1 (15 mg/mL) ratios were applied into the dogs' right and left ears, respectively, q 12 hr for 14 days. Based on video otoscopic examination, clinical score for canine OE (OTIS3) results before application were ≤1 for all dogs. During the study and at the conclusion, all scores remained ≤2, which is considered normal. No cytologic inflammatory cells were seen in any of the dogs' ears throughout the study. Different concentrations of enrofloxacin solution applied topically were well tolerated by dogs with healthy ears and can be considered for the treatment of dogs with bacterial OE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37708473/