Peer-reviewed veterinary case report
Toll-deficient Drosophila is susceptible to Pythium insidiosum infection.
- Journal:
- Microbiology and immunology
- Year:
- 2013
- Authors:
- Zanette, Régis A et al.
- Affiliation:
- Federal University of Santa Maria · United States
Abstract
There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of Tl pathway activation in fly immune response to pythiosis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23865688/