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Peer-reviewed veterinary case report

Tomographic molecular imaging and 3D quantification within adult mouse organs.

Journal:
Nature methods
Year:
2007
Authors:
Alanentalo, Tomas et al.
Affiliation:
University

Abstract

A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Based on combined improvements in sample preparation, tomographic imaging and computational processing, we present a procedure for high-resolution 3D quantification of structures within intact adult mouse organs. Using the nonobese diabetic (NOD) mouse model, we demonstrate a correlation between total islet beta-cell volume and the onset of type-1 diabetes.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/17143281/