Peer-reviewed veterinary case report
Topical asimadoline gel reduces itching and dermatitis in dogs
By Marsella, Rosanna et al.·Published in Experimental Dermatology·2021·Department of Small Animal Clinical Sciences College of Veterinary Medicine University of Florida Gainesville Florida USA, United States·View original on Crossref →
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Original publication title: Topical κ‐opioid receptor agonist asimadoline improves dermatitis in a canine model of atopic dermatitis
- Species:
- dog
Plain-English summary
A group of 14 beagles with atopic dermatitis (a skin condition causing itching and inflammation) were treated with a topical gel containing asimadoline, a κ-opioid receptor agonist, to see if it would improve their symptoms. Over four weeks, the dogs had their skin condition assessed after being exposed to allergens like house dust mites. The results showed that the dogs treated with the gel had a significant reduction in dermatitis severity compared to those receiving a placebo, although itching scores did not show a clear improvement. This treatment appears promising, and further studies with more frequent applications could be beneficial for dogs suffering from atopic dermatitis.
People also search for: dog skin problems treatment · beagle dermatitis relief · atopic dermatitis in dogs · topical treatments for dog itching
Abstract
AbstractThis prospective, 4‐week, placebo‐controlled, cross‐over study aimed to investigate the efficacy of 1% topical κ‐opioid agonist, asimadoline, in a model of canine atopic dermatitis (AD). Fourteen beagles were challenged with house dust mites every 3–4 days for a total of 9 challenges. Severity of dermatitis was assessed, and pruritus was monitored using GoPro HERO cameras. Pruritus scoring was evaluated at 10 time periods; baseline, 4 h post allergen challenge and the last day of the study on Day 28. Scoring was done blindly by personnel using BORIS software. A global subjective score was also given using a visual analogue scale (VAS). A 4‐week washout period occurred and dogs were crossed‐over, the study was repeated, and the results were analysed using combined data. Gel was applied once daily on inguinal area (0.6 ml/dog). ANOVA showed significant effect of time (p < 0.0001) and group (p = 0.0001) on dermatitis scores. Overall, no statistically significant effect on pruritus was found due to a crossing of scores on Day 17. Overtime the placebo scores increased while the active ingredient showed decrease after first 3 weeks. It is concluded that this approach is promising in dogs with AD and longer studies with more frequent application may be beneficial.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/exd.14507