Peer-reviewed veterinary case report
Topical aminocaproic acid helps heal dog corneal ulcers not healing
By Regnier, A et al.·Published in The Veterinary record·2005·Department of Clinical Sciences, France·View original on PubMed →
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Original publication title: Topical treatment of non-healing corneal epithelial ulcers in dogs with aminocaproic acid.
- Species:
- dog
Plain-English summary
A group of dogs with persistent corneal ulcers (sores on the surface of the eye) lasting more than 10 days were treated with a special eye solution called aminocaproic acid. After three weeks of treatment, 32 out of 34 eyes showed complete healing, while only 7 out of 17 eyes treated with a common antibiotic (gentamicin) healed. This suggests that aminocaproic acid is much more effective for this condition without any reported side effects. If your dog has a stubborn eye sore, ask your vet about this treatment option.
People also search for: dog corneal ulcer treatment · persistent eye sore in dogs · aminocaproic acid for dogs eye problems
Abstract
The potential efficacy of topical epsilon-aminocaproic acid, an antiplasmin agent, in the treatment of persistent corneal epithelial defects was evaluated in a study of the medical records of 44 dogs, in which 51 eyes had been diagnosed with a corneal epithelial defect lasting more than 10 days, with no apparent underlying cause. At an initial examination all the affected eyes had had non-adherent epithelium removed. Thirty-four of the eyes in 28 dogs examined between January 2000 and March 2003 were also treated by the topical application of a solution of 35.7 mg/ml ophthalmic aminocaproic acid three times a day; the other 17 eyes in 16 dogs treated between October 1997 and March 1999 had received only topical treatment with gentamicin in addition to the debridement. Both groups were assessed clinically at weekly intervals for a maximum of three weeks. The two groups had approximately the same breed distribution, and there were no statistically significant differences between them in terms of their age, sex, affected side or duration of the corneal erosions. After three weeks, 32 of the 34 eyes treated with aminocaproic acid (94.1 per cent) had been cured, compared with seven of the 17 eyes treated with gentamicin (41.2 per cent) (P=0.0001). No adverse drug reactions were reported.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16244233/