Peer-reviewed veterinary case report
Topical asimadoline gel reduces itching and dermatitis in dogs
By Marsella, Rosanna et al.·Published in Experimental dermatology·2022·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Topical κ-opioid receptor agonist asimadoline improves dermatitis in a canine model of atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of 14 beagles with atopic dermatitis (a skin condition causing itching and irritation) were treated with a topical gel containing asimadoline, a medication that targets specific receptors to help reduce symptoms. Over four weeks, the dogs showed improvement in their dermatitis scores, meaning their skin condition got better, while the placebo group did not see the same benefits. Although the itching did not show a significant change overall, the treatment appeared to help with the skin irritation. The researchers suggest that using this treatment more frequently and for a longer period could be beneficial for dogs with this condition.
People also search for: dog dermatitis treatment · beagle skin problems · atopic dermatitis in dogs · topical treatment for dog itching
Abstract
This prospective, 4-week, placebo-controlled, cross-over study aimed to investigate the efficacy of 1% topical κ-opioid agonist, asimadoline, in a model of canine atopic dermatitis (AD). Fourteen beagles were challenged with house dust mites every 3-4 days for a total of 9 challenges. Severity of dermatitis was assessed, and pruritus was monitored using GoPro HERO cameras. Pruritus scoring was evaluated at 10 time periods; baseline, 4 h post allergen challenge and the last day of the study on Day 28. Scoring was done blindly by personnel using BORIS software. A global subjective score was also given using a visual analogue scale (VAS). A 4-week washout period occurred and dogs were crossed-over, the study was repeated, and the results were analysed using combined data. Gel was applied once daily on inguinal area (0.6 ml/dog). ANOVA showed significant effect of time (p < 0.0001) and group (p = 0.0001) on dermatitis scores. Overall, no statistically significant effect on pruritus was found due to a crossing of scores on Day 17. Overtime the placebo scores increased while the active ingredient showed decrease after first 3 weeks. It is concluded that this approach is promising in dogs with AD and longer studies with more frequent application may be beneficial.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34839557/