Peer-reviewed veterinary case report
IgE and IgG antibody levels in Labradors and Goldens with atopic
By Lauber, Beatrice et al.·Published in Veterinary immunology and immunopathology·2012·Department of Clinical Research and Veterinary Public Health·View original on PubMed →
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Original publication title: Total IgE and allergen-specific IgE and IgG antibody levels in sera of atopic dermatitis affected and non-affected Labrador- and Golden retrievers.
- Species:
- dog
Plain-English summary
A study looked at Labrador and Golden retrievers with atopic dermatitis, a skin allergy that can cause itching and inflammation. Researchers found that Golden retrievers were more likely to have higher levels of certain antibodies related to allergies compared to Labradors. They also discovered that neutered dogs tended to have lower antibody levels. Interestingly, dogs with atopic dermatitis did not show higher levels of allergy-related antibodies against the tested allergens. The study suggests that allergen-specific immunotherapy (ASIT) can increase certain antibody levels, but it doesn't necessarily lower the overall allergy response. More research is needed to fully understand these findings.
People also search for: dog skin allergies treatment · Golden retriever itching · Labrador retriever allergy symptoms · atopic dermatitis in dogs · dog allergy testing
Abstract
Canine atopic dermatitis (CAD) is an allergic skin disease associated with IgE and IgG antibodies (Ab) to environmental allergens. The aim of this study was to determine which other factors influence serum Ab levels in CAD-affected and non-affected dogs as this has only been poorly investigated in dogs so far. Total and allergen-specific IgE levels and Dermatophagoides farinae (DF)-specific IgG1 and IgG4 were measured by ELISA in sera of 145 CAD-affected and 271 non-affected Labrador- and Golden retrievers. A multivariable logistic regression analysis including the factors age, breed, gender, castration, clinical CAD status and allergen-specific immunotherapy (ASIT) was performed. Golden retrievers had more frequently total (OR=1.87, 95% CI=1.26-2.87, p<0.01) and specific IgE levels above the threshold value than Labrador retrievers, suggesting that genetic factors influence IgE levels in dogs. Castration was generally associated with low Ab levels (OR=0.43-0.65, p<0.05). Surprisingly, dogs with CAD did not have increased odds for high IgE against any of the allergens tested. ASIT with DF was associated with high DF-specific IgG1 (OR=4.32, 95% CI 1.46-12.8, p<0.01) but was not associated with DF-specific IgG4 or decreased IgE levels. Further studies are needed to understand the role of allergen-specific IgE in CAD and of IgG1 in ASIT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22739207/