Peer-reviewed veterinary case report
Toxicity of the cyanobacterial neurotoxin beta-N-methylamino-L-alanine to three aquatic animal species.
- Journal:
- Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
- Year:
- 2009
- Authors:
- Purdie, Esme L et al.
- Affiliation:
- College of Life Sciences · United Kingdom
Abstract
Beta-N-methylamino-L-alanine (BMAA), a neurotoxin and candidate contributory cause of neurodegenerative diseases including amyotrophic lateral sclerosis, is produced by aquatic and terrestrial cyanobacteria. We have determined BMAA toxicity to three aquatic animal species: zebra fish (Danio rerio), brine shrimp (Artemia salina) and the protozoan Nassula sorex. Responses included: clonus convulsions and abnormal spinal axis formation (D. rerio), loss of phototaxis (A. salina) and mortalities (all species). These systems offer potential to further understand BMAA toxicity and the bioaccumulation and fates of BMAA in aquatic food chains leading to potential human exposure.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19929735/