Peer-reviewed veterinary case report
ВОЗБУДИТЕЛЬ ТОКСОПЛАЗМОЗА (TOXOPLASMA GONDII): ЛЕКАРСТВЕННАЯ РЕЗИСТЕНТНОСТЬ И ВИРУЛЕНТНОСТЬ ВОЗБУДИТЕЛЯ ПРИ МОДЕЛИРОВАНИИ ИНФЕКЦИИ В КЛЕТОЧНЫХ СИСТЕМАХ И НА МЫШАХ
- Journal:
- Ветеринарная патология
- Year:
- 2009
- Affiliation:
- ГНУ Всероссийский научно-исследовательский институт экспериментальной ветеринарии им. Я.Р. Коваленко (ВИЭВ) РАСХН · RU
- Species:
- rodent
Abstract
Pyrimethamine resistance production in embryonal lung Bos taurus cell culture (LEK) interfered with endodyogenie and resulted in the formation of multinucleated endozoite stages. Our virulence in vitro and in vivo assay suggest that as drug resistance increased the virulence in mice and cell system decreased. Some gradation between Toxoplasma sensibility and resistance permitted us to elaborate different models of Toxoplasma persistence: slow», chronic and latent infection.
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