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Peer-reviewed veterinary case report

Tramadol toxicity in a cat: case report and literature review of serotonin syndrome.

Journal:
Journal of feline medicine and surgery
Year:
2014
Authors:
Indrawirawan, Yenny & McAlees, Trudi
Affiliation:
Animal Accident and Emergency · Australia

Plain-English summary

This case report discusses a cat in Australia that experienced tramadol toxicity, which led to a condition called serotonin syndrome. The cat showed signs of this toxicity, and it was important for the veterinarians to act quickly by providing decontamination, monitoring, and supportive care as soon as symptoms appeared. In cases of severe overdose, the cat might need to stay in the hospital for a longer time. The report also reviews existing information about tramadol, its effects, and how to treat overdoses in cats, humans, and dogs. Overall, the treatment for this cat was effective in managing the symptoms of tramadol toxicity.

Abstract

OVERVIEW: Tramadol toxicity has not previously been reported in a cat. CASE SUMMARY: This report describes the clinical signs, diagnosis and treatment of tramadol toxicity, manifesting as serotonin syndrome, in a cat in Australia. PRACTICAL RELEVANCE: For any cat with suspicion of serotonin syndrome, in particular secondary to tramadol overdose, it is recommended that decontamination, monitoring and supportive care are instituted as soon as clinical signs develop. Prolonged hospitalisation may be required in the event of a severe overdose. LITERATURE REVIEW: The literature relating to the pharmacology of tramadol and tramadol overdose, clinical manifestations of tramadol overdose, and serotonin syndrome in cats, humans and dogs is reviewed. Recommended treatment for tramadol overdose and serotonin syndrome is also discussed.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/24966282/