Peer-reviewed veterinary case report
Immune gene differences in German shepherd dogs with atopic dermatitis
By Tengvall, K et al.·Published in Immunogenetics·2020·Department of Medical Biochemistry and Microbiology·View original on PubMed →
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Original publication title: Transcriptomes from German shepherd dogs reveal differences in immune activity between atopic dermatitis affected and control skin.
- Species:
- dog
Plain-English summary
A group of nine German shepherds with atopic dermatitis (a common itchy skin condition) had skin samples taken to study their immune response. Researchers found differences in gene activity between the affected dogs and healthy controls, particularly in genes related to inflammation and immune function. This research helps to understand how atopic dermatitis affects the skin and could lead to better treatments in the future. While the study is still in early stages, it highlights the importance of immune activity in managing this condition.
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Abstract
Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease with both genetic and environmental risk factors described. We performed mRNA sequencing of non-lesional axillary skin biopsies from nine German shepherd dogs. Obtained RNA sequences were mapped to the dog genome (CanFam3.1) and a high-quality skin transcriptome was generated with 23,510 expressed gene transcripts. Differentially expressed genes (DEGs) were defined by comparing three controls to five treated CAD cases. Using a leave-one-out analysis, we identified seven DEGs: five known to encode proteins with functions related to an activated immune system (CD209, CLEC4G, LOC102156842 (lipopolysaccharide-binding protein-like), LOC480601 (regakine-1-like), LOC479668 (haptoglobin-like)), one (OBP) encoding an odorant-binding protein potentially connected to rhinitis, and the last (LOC607095) encoding a novel long non-coding RNA. Furthermore, high mRNA expression of inflammatory genes was found in axillary skin from an untreated mild CAD case compared with healthy skin. In conclusion, we define genes with different expression patterns in CAD case skin helping us understand post-treatment atopic skin. Further studies in larger sample sets are warranted to confirm and to transfer these results into clinical practice.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32556497/