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Peer-reviewed veterinary case report

Transfer of specific antibodies results in increased expression of TNF-alpha and IL12 and recruitment of neutrophils to the site of a cutaneous Francisella tularensis infection.

Journal:
Journal of medical microbiology
Year:
2004
Authors:
Stenmark, Stephan & Sjöstedt, Anders
Affiliation:
University
Species:
rodent

Abstract

This study demonstrates that passive transfer of Francisella tularensis-specific antibodies before experimental cutaneous infection with the live vaccine strain of F. tularensis has profound effects. Recipient mice showed stronger staining for TNF-alpha and IL12, and larger numbers of neutrophils in skin samples after infection than control mice.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/15150328/