Peer-reviewed veterinary case report
Transforming growth factor-{beta} regulates susceptibility of epithelial apoptosis in murine model of colitis.
- Journal:
- Annals of the New York Academy of Sciences
- Year:
- 2004
- Authors:
- Sakuraba, Hirotake et al.
- Affiliation:
- First Department of Internal Medicine · Japan
Abstract
Transforming growth factor (TGF)-beta has a key role in intestinal homeostasis. Our present data suggest that TGF-beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF-beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon-gamma in DSS-induced colitis.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15681787/