Peer-reviewed veterinary case report
Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model.
- Journal:
- Parkinsonism & related disorders
- Year:
- 2020
- Authors:
- Alvarez-Fischer, D et al.
- Affiliation:
- Institute of Neurogenetics · Germany
Abstract
Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32906083/