Peer-reviewed veterinary case report
Transgenic plants for the production of veterinary vaccines.
- Journal:
- Immunology and cell biology
- Year:
- 2005
- Authors:
- Dus Santos, María José & Wigdorovitz, Andrés
- Affiliation:
- Veterinary and Agronomy Research Center
Plain-English summary
Researchers are exploring the use of genetically modified plants, specifically alfalfa, to create new types of vaccines for cattle. This method focuses on producing edible vaccines that can help protect against serious viruses like foot and mouth disease, bovine rotavirus, and bovine viral diarrhea, which cause significant economic losses in cattle farming in Argentina. The study reviews how well these plants can produce proteins that trigger an immune response against these viruses. The findings suggest that using plants for vaccine development could be a promising alternative for immunizing cattle.
Abstract
The expression of antigens in transgenic plants has been increasingly used in the development of experimental vaccines, particularly oriented to the development of edible vaccines. Hence, this technology becomes highly suitable to express immunogenic proteins from pathogens. Foot and mouth disease virus, bovine rotavirus and bovine viral diarrhoea virus are considered to be the most important causative agents of economic loss of cattle production in Argentina, and they are thus optimal candidates for alternative means of immunization. Here, we present a review of our results corresponding to the expression of immunogenic proteins from these three viruses in alfalfa transgenic plants, and we discuss the possibility of using them for the development of plant-based vaccines.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15877600/