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Peer-reviewed veterinary case report

Transient Fanconi syndrome in Quarter horses.

Journal:
The Canadian veterinary journal = La revue veterinaire canadienne
Year:
2014
Authors:
Ohmes, Cameon M et al.
Affiliation:
Department of Clinical Sciences · United States
Species:
horse

Plain-English summary

Two Quarter horses were experiencing weight loss and tests showed they had sugar in their urine, normal blood sugar levels, and a slight imbalance in their body chemistry, which suggested a problem with their kidneys. Additional tests revealed they also had high levels of certain amino acids and lactic acid in their urine, confirming a condition known as Fanconi syndrome, which affects kidney function. Fortunately, both horses received supportive treatment and made a full recovery. This case is notable as it is the first documented instance of acquired Fanconi syndrome in horses.

Abstract

Two Quarter horses with weight loss had glucosuria, euglycemia, and a mild metabolic acidosis suggesting a proximal renal tubular defect. Further testing revealed transient generalized aminoaciduria, lactic aciduria, and glucosuria, indicating Fanconi syndrome. Both horses recovered with supportive therapy. This is the first report of acquired Fanconi syndrome in horses.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/24489393/