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Peer-reviewed veterinary case report

Dog with kidney acid problem and Fanconi syndrome recovers

By Hostutler, Roger A et al.·Published in Journal of the American Veterinary Medical Association·2004·Department of Veterinary Clinical Sciences, United States·View original on PubMed

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Original publication title: Transient proximal renal tubular acidosis and Fanconi syndrome in a dog.

Species:
dog

Plain-English summary

A 9-year-old spayed female Labrador Retriever was brought to the vet because she was not eating, seemed very tired, and was vomiting for five days. Tests showed she had several serious issues, including kidney problems and a condition called Fanconi syndrome, which affects how the kidneys handle certain substances. The vet treated her with antibiotics and medications to help balance her electrolytes. After treatment, her symptoms improved, and she returned to normal health within eight months.

People also search for: dog vomiting and lethargy · Labrador kidney problems · Fanconi syndrome treatment in dogs

Abstract

A 9-year-old spayed female Labrador Retriever was evaluated for anorexia, lethargy, and vomiting of 5 days' duration. Laboratory abnormalities included azotemia, high liver enzyme activities, hyperchloremic metabolic acidosis, glucosuria, ketonuria, proteinuria, and aminoaciduria. These laboratory abnormalities were diagnostic of proximal renal tubular acidosis and Fanconi syndrome. Results of initial and convalescent serologic tests for leptospirosis were negative. The dog was treated with amoxicillin, sodium bicarbonate, and potassium citrate at discharge. Repeated evaluations revealed resolution of the acidosis, azotemia, proteinuria, glucosuria, ketonuria, and high liver enzyme activities. Alkali administration was gradually discontinued, and the dog was clinically normal 8 months after discharge. The dog's clinical condition appeared to have been transient in nature, a phenomenon that is rarely seen in human or veterinary medicine.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15154730/