Peer-reviewed veterinary case report
Contagious genital cancer spread between two dogs in the UK
By Hayes, A M et al.·Published in The Journal of small animal practice·2023·Department of Veterinary Medicine, United Kingdom·View original on PubMed →
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Original publication title: Transmission of canine transmissible venereal tumour between two dogs in the UK.
- Species:
- dog
Plain-English summary
A dog in the UK was diagnosed with a contagious cancer called canine transmissible venereal tumor (CTVT) after being imported from a region where it is more common. This cancer can spread between dogs through direct contact, and unfortunately, it was transmitted to a second dog, even though that dog was neutered. Both dogs experienced aggressive disease progression, which included spreading of the cancer and resistance to treatment, leading to their euthanasia. This case highlights the importance of being aware of CTVT, especially when bringing in dogs from areas where the disease is prevalent.
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Abstract
Canine transmissible venereal tumour (CTVT) is a contagious cancer spread by transfer of living cancer cells. Occasional cases are observed in the UK in dogs imported from endemic regions. Here, we report a case of imported canine transmissible venereal tumour that was transmitted to a second dog within the UK. Transmission of genital canine transmissible venereal tumour occurred despite neutered status of the second dog. The aggressive course of disease in both cases, which included metastasis, resistance to therapeutic interventions and ultimate euthanasia of both dogs, is described. The diagnosis of canine transmissible venereal tumour was made using a combination of cytology, histology, immunohistochemistry and PCR to detect the LINE-MYC rearrangement. Practitioners unfamiliar with canine transmissible venereal tumour are reminded of this disease of concern, particularly when imported dogs are placed in multi-dog households, irrespective of neuter status.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36990106/