Peer-reviewed veterinary case report
Transplantation and Monitoring of a Murine Minor Histocompatibility Antigen-Mismatched Model of Graft-Versus-Host Disease.
- Journal:
- Methods in molecular biology (Clifton, N.J.)
- Year:
- 2025
- Authors:
- Shamshirian, Amir et al.
- Affiliation:
- QIMR Berghofer Medical Research Institute · Australia
Abstract
Murine models of allogeneic stem cell transplantation (allo-SCT) have been a valuable tool in expanding our understanding of graft-versus-host disease (GVHD) immunopathology, providing a platform to manipulate allo-SCT and mimic the clinical scenarios observed in humans. These systems have been instrumental in advancing our understanding of the disease mechanisms and facilitating the exploration of novel therapeutic strategies. This chapter outlines the transplantation and monitoring methods in a murine minor histocompatibility antigen-mismatched model of GVHD model using C3H.SW donors and C57BL/6J recipients, aiming to provide researchers with a comprehensive guide to effectively use this model for advancing GVHD treatment and improving patient outcomes in allo-SCT.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/40100597/