Peer-reviewed veterinary case report
How to treat Haemaphysalis longicornis ticks on dogs with Simparica
By Kryda, Kristina et al.·Published in Parasites & vectors·2025·Zoetis, United States·View original on PubMed →
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Original publication title: Treatment and control of Haemaphysalis longicornis infestations on dogs using a formulation of sarolaner, moxidectin and pyrantel (Simparica Trio®).
- Species:
- dog
Plain-English summary
A group of dogs infested with a type of tick called Haemaphysalis longicornis was treated with a medication called Simparica Trio, which combines three active ingredients. After just one dose, the treatment was found to be 98.9% effective in killing the ticks and preventing new infestations for over a month. The dogs that received Simparica Trio had significantly fewer ticks compared to those that received a placebo, and there were no side effects reported. This means that Simparica Trio is a reliable option for controlling tick infestations in dogs.
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Abstract
BACKGROUND: Simparica Trio(Zoetis), an orally administered combination product for dogs containing sarolaner, moxidectin and pyrantel pamoate, was evaluated against Haemaphysalis longicornis, a tick species originally native to Asia but now found on multiple continents, including North America. METHODS: Two groups of eight dogs each were ranked based on pretreatment tick counts and then allocated through randomization to treatment on Day 0 with a single dose of either placebo or Simparica Trio at the minimum label dose of 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt). Dogs were infested with 50 viable adult H. longicornis on Days -2, 5, 12, 19, 26 and 33. Tick counts were conducted for all dogs 48 h after treatment and subsequent re-infestations. RESULTS: Simparica Trio was 98.9% effective in treating existing H. longicornis infestation when considering live attached (feeding) ticks. Efficacy remained > 98% in preventing re-infestation for at least 35 days, and the geometric mean live attached tick counts for Simparica Trio-treated dogs were significantly lower than for placebo-treated dogs (P < 0.0001) at all timepoints assessed in the study. Dogs treated with Simparica Trio also had significantly lower (P < 0.0001) geometric mean total live (attached and free) tick counts than placebo-treated dogs at all times. No adverse events were reported for any dogs throughout the duration of the study. CONCLUSIONS: A single administration of Simparica Trio at minimum label dose was efficacious in treating and controlling adult H. longicornis in dogs for more than one month.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40140872/