Peer-reviewed veterinary case report
Goat treated for flunixin overdose with lipid emulsion and plasma
By Butty, Emmanuelle Marie et al.·Published in Journal of veterinary internal medicine·2021·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus).
Plain-English summary
A 12-week-old Nigerian dwarf goat was hospitalized after a surgery for urinary stones and accidentally received a dose of a pain medication (flunixin meglumine) that was 16 times higher than what he should have gotten. To treat this overdose, the veterinarians used a special fat solution (lipid emulsion) and a procedure called therapeutic plasma exchange to remove the excess medication from his system. They carefully adjusted the treatment to prevent complications, and after the procedures, the goat showed no signs of gastrointestinal or kidney problems from the overdose. This case highlights effective ways to manage medication overdoses in young goats.
People also search for: goat overdose treatment · flunixin meglumine side effects in goats · Nigerian dwarf goat health issues
Abstract
A 12 week-old Nigerian dwarf (Capra aegagrus hircus) buck kid was hospitalized for management of obstructive urolithiasis. Postoperatively, he was inadvertently administered 16-times greater than his calculated dose of a nonsteroidal anti-inflammatory drug (NSAID; 17.5 mg/kg flunixin meglumine, IV). The goat was treated with intravenous administration of lipid emulsion (ILE) prior to membrane-based therapeutic plasma exchange (mTPE) under general anesthesia. The increased coagulability inherent to small ruminants in comparison with dogs and cats warranted specific adjustments in the prescription of anticoagulation, blood flow, and filtration fraction to avoid circuit clotting during mTPE. Serum flunixin meglumine concentration measured before, during, and after mTPE revealed marked reduction in drug concentration. After the combined treatments, no clinical evidence of NSAID gastrointestinal or renal toxicosis was detected. This case report describes successful management of flunixin meglumine overdose in a small ruminant using combined ILE and mTPE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33934401/