Peer-reviewed veterinary case report
Radioactive iodine treatment for malignant adrenal tumor in a dog
By Bommarito, David A et al.·Published in Journal of the American Animal Hospital Association·2011·Department of Veterinary Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Treatment of a malignant pheochromocytoma in a dog using 131I metaiodobenzylguanidine.
- Species:
- dog
Plain-English summary
A 12-year-old male Yorkshire terrier was brought in with a large abdominal mass that was diagnosed as an inoperable pheochromocytoma, a type of tumor affecting the adrenal glands. After receiving a radioactive treatment called metaiodobenzylguanidine (MIBG), the dog showed stable disease for about a month and a half. Unfortunately, the tumor progressed after five months, and a second treatment was given. Sadly, the dog passed away three weeks later due to complications from the tumor affecting the intestines.
People also search for: dog abdominal mass treatment · Yorkshire terrier pheochromocytoma · MIBG treatment for dog tumor
Abstract
A 12 yr old castrated male Yorkshire terrier was presented with a history of an inoperable pheochromocytoma. Physical examination revealed a large, midabdominal mass. Neurologic examination was normal at presentation. An abdominal computed tomography scan revealed a 215 cm(3) mass in the region of the right kidney. Forty-eight hours after IV injection of 370 megabecquerels (MBq, equivalent to10 millicuries [mCi]) of metaiodobenzylguanidine labeled with radioactive iodine ([(131)I]MIBG), standard planar scintigraphy was performed. A diffuse area of moderate uptake was noted in the midabdominal region. The dog experienced stable disease for 1.5 mo after injection based on a follow-up computed tomography (CT) scan; however, 5 mo after injection, repeat CT imaging revealed progression of the tumor, and a second IV injection of 370 MBq (10 mCi) of [(131)I]MIBG was administered. The dog died 3 wk after the second injection as a result of gastrointestinal blood loss that was believed to be caused by compression-induced bowel ischemia by the mass. A full necropsy was not performed, but the mass was removed for histologic evaluation, which confirmed the diagnosis of pheochromocytoma. This report is the first to document the treatment of canine pheochromocytoma using [(131)I]MIBG.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22058369/