Peer-reviewed veterinary case report
Canine vocal fold scar treated with growth factor injection
By Suehiro, Atsushi et al.·Published in Acta oto-laryngologica·2010·Department of Otolaryngology-Head & Neck Surgery, Japan·View original on PubMed →
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Original publication title: Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor: a canine study.
- Species:
- dog
Plain-English summary
A group of eight beagles with injured vocal folds received either a special growth factor injection or a saline solution to see which helped their vocal cords heal better. The beagles treated with the growth factor showed improved vocal function and less scarring compared to those who received the saline. After five months, the treated vocal folds had better structure and function, indicating that the growth factor helped restore their vocal abilities. This treatment could be a promising option for dogs with vocal fold injuries.
People also search for: dog vocal fold injury treatment · beagle voice problems · canine laryngeal injury recovery
Abstract
CONCLUSIONS: Results of the current study revealed improved phonation threshold pressure (PTP), normalized mucosal wave amplitude (NMWA), and less contraction of the lamina propria in injured larynges treated with basic fibroblast growth factor (bFGF). OBJECTIVES: We investigated the effects of local injection of bFGF for treatment of acute vocal fold injury in a canine model. METHODS: Vocal folds of eight beagles were unilaterally injured by removal of the mucosa under direct laryngoscopy. Four beagles received local injections of bFGF delivered to the scarred vocal fold at 1 month after injury. The remaining four beagles received local injections of saline and served as a sham-treatment group. Larynges were harvested 5 months after treatment and excised larynx experiments were performed to measure PTP, NMWA, and normalized glottal gap (NGG). Histologic staining was performed to evaluate structural changes of the extracellular matrix. RESULTS: Excised larynx measurements revealed significantly lower PTP and increased NMWA in bFGF-treated vocal fold. Elastica Van Gieson staining revealed less contraction of the bFGF-treated vocal fold. Histologic measurements revealed that the thickness of the lamina propria was significantly greater in the bFGF-treated vocal fold. Alcian blue staining revealed improved restoration of hyaluronic acid in the bFGF-treated vocal fold.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20082571/